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KMID : 0369819990290010001
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Jorunal of Korean Pharmaceutical Sciences
1999 Volume.29 No. 1 p.1 ~ p.5
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Bioavailability of Emulsion Containing Scutellariae Radix Extract
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양재헌/Yang JH
김영일/KIm YI
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Abstract
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The bioavailabilities of baicalin in water, oil, w/o and o/w emulsion were evaluated in rats. The dissolution rate of baicalin in o/w emulsion was smaller than those of w/o form in dilute hydrochloric acid solution (pH 1.2) and in PBS (pH 6.8). The absorption rate of baicalin from w/o emulsion was smaller than that of o/w emulsion in the different parts of rat intestine of the rats. Following oral administration in rats, the Cmax of baicalin from water phase, oil phase, o/w wand w/o emulsion were 2.11, 0.61, 1.57, and 1.35μg/ml, respectively. The relative bioavailability of w/o emusion was 129 % when it was compared with water phase. This result suggests that the improvement of bioavailability for baicalin in w/o emulsion might be practically available.
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KEYWORD
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Scutellariae Radix, Emulsion, Baicalin, Blood concentration, Intestinal absorption, Bioavailability
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